Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Transforming growth factor-α (TGFα) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmonary fibrosis. EGFR signaling activates several intracellular signaling pathways including...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Le Cras, Timothy D., Korfhagen, Thomas R., Davidson, Cynthia, Schmidt, Stephanie, Fenchel, Matthew, Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2010
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808075/
https://ncbi.nlm.nih.gov/pubmed/20042669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090123
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