The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

Acute hypoxic vasoconstriction and development of hypoxic pulmonary hypertension (PHTN) are unique properties of the pulmonary circulation. The pulmonary endothelium produces vasoactive factors, including nitric oxide (NO), that modify these phenomena. We tested the hypothesis that NO produced by en...

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Detalhes bibliográficos
Main Authors: Fagan, Karen A., Fouty, Brian W., Tyler, Robert C., Morris, Kenneth G., Hepler, Lisa K., Sato, Koichi, LeCras, Timothy D., Abman, Steven H., Weinberger, Howard D., Huang, Paul L., McMurtry, Ivan F., Rodman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC407877/
https://ncbi.nlm.nih.gov/pubmed/9916141
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