Effect of Zymogen Domains and Active Site Occupation on Activation of Prothrombin by von Willebrand Factor-binding Protein

著者: Kroh, Heather K., Bock, Paul E.
出版事項 2012

Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin

著者: Kroh, Heather K., Panizzi, Peter, Bock, Paul E.
出版事項 2009

Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function

著者: Huang, Xin, Swanson, Richard, Kroh, Heather K., Bock, Paul E.
出版年 J Biol Chem (2019)

Skizzle Is a Novel Plasminogen- and Plasmin-binding Protein from Streptococcus agalactiae That Targets Proteins of Human Fibrinolysis to Promote Plasmin Generation

著者: Wiles, Karen G., Panizzi, Peter, Kroh, Heather K., Bock, Paul E.
出版事項 2010

Expression of Allosteric Linkage between the Sodium Ion Binding Site and Exosite I of Thrombin during Prothrombin Activation

著者: Kroh, Heather K., Tans, Guido, Nicolaes, Gerry A. F., Rosing, Jan, Bock, Paul E.
出版事項 2007

Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions

著者: Panizzi, Peter, Friedrich, Rainer, Fuentes-Prior, Pablo, Kroh, Heather K., Briggs, Judy, Tans, Guido, Bode, Wolfram, Bock, Paul E.
出版事項 2005

Active Site-labeled Prothrombin Inhibits Prothrombinase in Vitro and Thrombosis in Vivo

著者: Kroh, Heather K., Panizzi, Peter, Tchaikovski, Svetlana, Baird, T. Regan, Wei, Nancy, Krishnaswamy, Sriram, Tans, Guido, Rosing, Jan, Furie, Bruce, Furie, Barbara C., Bock, Paul E.
出版事項 2011

Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin

著者: Maddur, Ashoka A., Kroh, Heather K., Aschenbrenner, Mary E., Gibson, Breanne H. Y., Panizzi, Peter, Sheehan, Jonathan H., Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.
出版年 J Biol Chem (2020)

Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface

著者: Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Ohi, Melanie D., Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Spiller, Benjamin W., Lacy, D. Borden
出版年 J Biol Chem (2017)

Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin

著者: Tam, John, Icho, Simoun, Utama, Evelyn, Orrell, Kathleen E., Gómez-Biagi, Rodolfo F., Theriot, Casey M., Kroh, Heather K., Rutherford, Stacey A., Lacy, D. Borden, Melnyk, Roman A.
出版年 Proc Natl Acad Sci U S A (2020)

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells

著者: Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Zhang, Zhifen, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Melnyk, Roman A., Spiller, Benjamin W., Lacy, D. Borden
出版年 J Biol Chem (2018)

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants

著者: Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.
出版年 J Biol Chem (2017)

Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis

著者: Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Laubacher, Erin N., Thomas, Audrey K., Kroh, Heather K., Childress, Kevin O., Peritore-Galve, F. Christopher, Washington, M. Kay, Coffey, Robert J., Lacy, D. Borden
出版年 Infect Immun (2021)

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities

著者: Quesada-Gómez, Carlos, López-Ureña, Diana, Chumbler, Nicole, Kroh, Heather K., Castro-Peña, Carolina, Rodríguez, César, Orozco-Aguilar, Josué, González-Camacho, Sara, Rucavado, Alexandra, Guzmán-Verri, Caterina, Lawley, Trevor D., Lacy, D. Borden, Chaves-Olarte, Esteban
出版年 Infect Immun (2016)

Control of antiviral innate immune response by protein geranylgeranylation

著者: Yang, Shigao, Harding, Alfred T., Sweeney, Catherine, Miao, David, Swan, Gregory, Zhou, Connie, Jiang, Zhaozhao, Fitzgerald, Katherine A., Hammer, Gianna, Bergo, Martin O., Kroh, Heather K., Lacy, D. Borden, Sun, Chunxiang, Glogauer, Michael, Que, Loretta G., Heaton, Nicholas S., Wang, Donghai
出版年 Sci Adv (2019)

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

著者: Panizzi, Peter, Nahrendorf, Matthias, Figueiredo, Jose-Luiz, Panizzi, Jennifer, Marinelli, Brett, Iwamoto, Yoshi, Keliher, Edmund, Maddur, Ashoka A., Waterman, Peter, Kroh, Heather K., Leuschner, Florian, Aikawa, Elena, Swirski, Filip K., Pittet, Mikael J., Hackeng, Tilman M., Fuentes-Prior, Pablo, Schneewind, Olaf, Bock, Paul E., Weissleder, Ralph
出版事項 2011

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab

著者: Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.
出版年 J Mol Biol (2017)