Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities

Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still poorly understood. During a C. difficile outbreak, a strain from this clade was f...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Quesada-Gómez, Carlos, López-Ureña, Diana, Chumbler, Nicole, Kroh, Heather K., Castro-Peña, Carolina, Rodríguez, César, Orozco-Aguilar, Josué, González-Camacho, Sara, Rucavado, Alexandra, Guzmán-Verri, Caterina, Lawley, Trevor D., Lacy, D. Borden, Chaves-Olarte, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771349/
https://ncbi.nlm.nih.gov/pubmed/26755157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01291-15
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