Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab

The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced by the bacterial pathogen Clostridium difficile and are responsible for the pathology associated with C. difficile infection (CDI). The antitoxin antibodies actoxumab and bezlotoxumab bind to and neutralize TcdA and TcdB, respectively. Bez...

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Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373199/
https://ncbi.nlm.nih.gov/pubmed/28232034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.02.010
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