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Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants
Clostridium difficile is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human disease. TcdA and TcdB are large, multidomain proteins, each harboring a cytotoxic glucosyltransferase domain that is delivered into the cytosol f...
שמור ב:
| הוצא לאור ב: | J Biol Chem |
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| Main Authors: | , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5655507/ https://ncbi.nlm.nih.gov/pubmed/28842504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806687 |
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