Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants

Clostridium difficile is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human disease. TcdA and TcdB are large, multidomain proteins, each harboring a cytotoxic glucosyltransferase domain that is delivered into the cytosol f...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655507/
https://ncbi.nlm.nih.gov/pubmed/28842504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806687
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