Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for TcdB, but its pathophysiological rel...

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Publicat a:Nat Commun
Autors principals: Chen, Peng, Zeng, Ji, Liu, Zheng, Thaker, Hatim, Wang, Siyu, Tian, Songhai, Zhang, Jie, Tao, Liang, Gutierrez, Craig B., Xing, Li, Gerhard, Ralf, Huang, Lan, Dong, Min, Jin, Rongsheng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213806/
https://ncbi.nlm.nih.gov/pubmed/34145250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23878-3
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