Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile

Clostridioides difficile is the causative bacterium in 15–20% of all antibiotic associated diarrheas. The symptoms associated with C. difficile infection (CDI) are primarily induced by the two large exotoxins TcdA and TcdB. Both toxins enter target cells by receptor-mediated endocytosis. Although di...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Fühner, Viola, Heine, Philip Alexander, Helmsing, Saskia, Goy, Sebastian, Heidepriem, Jasmin, Loeffler, Felix F., Dübel, Stefan, Gerhard, Ralf, Hust, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291526/
https://ncbi.nlm.nih.gov/pubmed/30574127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02908
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