Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling

Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrhea and primarily involve two exotoxins, TcdA and TcdB. Actoxumab and bezlotoxumab are human monoclonal antibodies that neutralize the cytotoxic/cytopathic effects of TcdA and TcdB, respectively. In a...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Hernandez, Lorraine D., Racine, Fred, Xiao, Li, DiNunzio, Edward, Hairston, Nichelle, Sheth, Payal R., Murgolo, Nicholas J., Therien, Alex G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335902/
https://ncbi.nlm.nih.gov/pubmed/25451052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04433-14
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