Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis

Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly kill cells and induce an inflammatory response in t...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Laubacher, Erin N., Thomas, Audrey K., Kroh, Heather K., Childress, Kevin O., Peritore-Galve, F. Christopher, Washington, M. Kay, Coffey, Robert J., Lacy, D. Borden
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Molecular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090962/
https://ncbi.nlm.nih.gov/pubmed/33468584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00543-20
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