Skizzle Is a Novel Plasminogen- and Plasmin-binding Protein from Streptococcus agalactiae That Targets Proteins of Human Fibrinolysis to Promote Plasmin Generation

Skizzle (SkzL), secreted by Streptococcus agalactiae, has moderate sequence identity to streptokinase and staphylokinase, bacterial activators of human plasminogen (Pg). SkzL binds [Glu]Pg with low affinity (K(D) 3–16 μm) and [Lys]Pg and plasmin (Pm) with indistinguishable high affinity (K(D) 80 and...

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Hlavní autoři: Wiles, Karen G., Panizzi, Peter, Kroh, Heather K., Bock, Paul E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898333/
https://ncbi.nlm.nih.gov/pubmed/20435890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107730
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