Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface

Clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. Disease symptoms stem from the activities of two large, multidomain toxins known as TcdA and TcdB. The toxins can bind, enter, and perturb host cell function through a multis...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Ohi, Melanie D., Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Spiller, Benjamin W., Lacy, D. Borden
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582835/
https://ncbi.nlm.nih.gov/pubmed/28705932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781112
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