p16(INK4a) reporter mice reveal age-promoting effects of environmental toxicants

Por Sorrentino, Jessica A., Krishnamurthy, Janakiraman, Tilley, Stephen, Alb, James G., Burd, Christin E., Sharpless, Norman E.
Publicado em 2013

Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

Por Liu, Yan, Johnson, Soren M., Fedoriw, Yuri, Rogers, Arlin B., Yuan, Hong, Krishnamurthy, Janakiraman, Sharpless, Norman E.
Publicado em 2011

Overexpression of the Cell Cycle Inhibitor p16(INK4a) Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice

Por Cardenas, Jessica C., Owens, A. Phillip, Krishnamurthy, Janakiraman, Sharpless, Norman E., Whinna, Herbert C., Church, Frank C.
Publicado em 2011

Ink4a/Arf expression is a biomarker of aging

Por Krishnamurthy, Janakiraman, Torrice, Chad, Ramsey, Matthew R., Kovalev, Grigoriy I., Al-Regaiey, Khalid, Su, Lishan, Sharpless, Norman E.
Publicado em 2004

Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

Por Nelson, Julie A. E., Krishnamurthy, Janakiraman, Menezes, Prema, Liu, Yan, Hudgens, Michael G., Sharpless, Norman E., Eron, Joseph J.
Publicado em 2012

Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing

Por Molofsky, Anna V., Slutsky, Shalom G., Joseph, Nancy M., He, Shenghui, Pardal, Ricardo, Krishnamurthy, Janakiraman, Sharpless, Norman E., Morrison, Sean J.
Publicado em 2006

Chemotherapy and Stem Cell Transplantation Increase p16(INK4a) Expression, a Biomarker of T-cell Aging

Por Wood, William A., Krishnamurthy, Janakiraman, Mitin, Natalia, Torrice, Chad, Parker, Joel S., Snavely, Anna C., Shea, Thomas C., Serody, Jonathan S., Sharpless, Norman E.
Publicado no EBioMedicine (2016)

Monitoring Tumorigenesis and Senescence In Vivo with a p16(INK4a)-Luciferase Model

Por Burd, Christin E., Sorrentino, Jessica A., Clark, Kelly S., Darr, David B., Krishnamurthy, Janakiraman, Deal, Allison M., Bardeesy, Nabeel, Castrillon, Diego H., Beach, David H., Sharpless, Norman E.
Publicado em 2013

Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence

Por Liu, Jie-Yu, Souroullas, George P., Diekman, Brian O., Krishnamurthy, Janakiraman, Hall, Brandon M., Sorrentino, Jessica A., Parker, Joel S., Sessions, Garrett A., Gudkov, Andrei V., Sharpless, Norman E.
Publicado no Proc Natl Acad Sci U S A (2019)

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation

Por Kuo, Chao-Ling, Murphy, Andrew J., Sayers, Scott, Li, Rong, Yvan-Charvet, Laurent, Davis, Jaeger Z., Krishnamurthy, Janakiraman, Liu, Yan, Puig, Oscar, Sharpless, Norman E., Tall, Alan R., Welch, Carrie L.
Publicado em 2011

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

Por Sanoff, Hanna K., Deal, Allison M., Krishnamurthy, Janakiraman, Torrice, Chad, Dillon, Patrick, Sorrentino, Jessica, Ibrahim, Joseph G., Jolly, Trevor A., Williams, Grant, Carey, Lisa A., Drobish, Amy, Gordon, Brittaney-Belle, Alston, Shani, Hurria, Arti, Kleinhans, Karin, Rudolph, K. Lenhard, Sharpless, Norman E., Muss, Hyman B.
Publicado em 2014