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Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this cancer-aging hypothesis has been elusive. Here, by using somatic, tissue-specific inactivation of the p16(INK4a) tumor suppressor in murine T- or B-lympho...

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Detalhes bibliográficos
Main Authors: Liu, Yan, Johnson, Soren M., Fedoriw, Yuri, Rogers, Arlin B., Yuan, Hong, Krishnamurthy, Janakiraman, Sharpless, Norman E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069667/
https://ncbi.nlm.nih.gov/pubmed/21245485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-304402
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