Overexpression of the Cell Cycle Inhibitor p16(INK4a) Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice

OBJECTIVE: Age-associated cellular senescence is thought to promote vascular dysfunction. p16(INK4a) is a cell cycle inhibitor that promotes senescence and is upregulated during normal aging. In this study, we examine the contribution of p16(INK4a) overexpression on venous thrombosis. METHODS AND RE...

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Detaylı Bibliyografya
Asıl Yazarlar: Cardenas, Jessica C., Owens, A. Phillip, Krishnamurthy, Janakiraman, Sharpless, Norman E., Whinna, Herbert C., Church, Frank C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086817/
https://ncbi.nlm.nih.gov/pubmed/21233453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221721
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