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Overexpression of the Cell Cycle Inhibitor p16(INK4a) Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice
OBJECTIVE: Age-associated cellular senescence is thought to promote vascular dysfunction. p16(INK4a) is a cell cycle inhibitor that promotes senescence and is upregulated during normal aging. In this study, we examine the contribution of p16(INK4a) overexpression on venous thrombosis. METHODS AND RE...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086817/ https://ncbi.nlm.nih.gov/pubmed/21233453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221721 |
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