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Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing
Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells1,2. It has been proposed that this is at least partially caused by the senescence of progenitors with age3,4; however, it has not yet been tested whether genes associated with senescence functionally...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586960/ https://ncbi.nlm.nih.gov/pubmed/16957738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05091 |
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