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Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing

Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells1,2. It has been proposed that this is at least partially caused by the senescence of progenitors with age3,4; however, it has not yet been tested whether genes associated with senescence functionally...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Molofsky, Anna V., Slutsky, Shalom G., Joseph, Nancy M., He, Shenghui, Pardal, Ricardo, Krishnamurthy, Janakiraman, Sharpless, Norman E., Morrison, Sean J.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2006
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586960/
https://ncbi.nlm.nih.gov/pubmed/16957738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05091
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