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Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing

Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells1,2. It has been proposed that this is at least partially caused by the senescence of progenitors with age3,4; however, it has not yet been tested whether genes associated with senescence functionally...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Molofsky, Anna V., Slutsky, Shalom G., Joseph, Nancy M., He, Shenghui, Pardal, Ricardo, Krishnamurthy, Janakiraman, Sharpless, Norman E., Morrison, Sean J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586960/
https://ncbi.nlm.nih.gov/pubmed/16957738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05091
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