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Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo

The Polycomb gene Bmi-1 is required for the self-renewal of stem cells from diverse tissues, including the central nervous system (CNS). Bmi-1 expression is elevated in most human gliomas, irrespective of grade, raising the question of whether Bmi-1 over-expression is sufficient to promote self-rene...

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Bibliografische gegevens
Hoofdauteurs: He, Shenghui, Iwashita, Toshihide, Buchstaller, Johanna, Molofsky, Anna V., Thomas, Dafydd, Morrison, Sean J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996717/
https://ncbi.nlm.nih.gov/pubmed/19389366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.01.020
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