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Ink4a/Arf expression is a biomarker of aging
The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16(INK4a) and Arf, which are principal mediators of cellular senescence. To study the links between senescence and aging in vivo, we examined Ink4a/Arf expression in rodent models of aging. We show that expression of p16(INK4a) and Arf marke...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524230/ https://ncbi.nlm.nih.gov/pubmed/15520862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422475 |
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