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Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. This theory has been limited, however, by an inability to identify and isolate individual senescent cells within an intact organism. T...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377452/ https://ncbi.nlm.nih.gov/pubmed/30683717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818313116 |
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