Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence

The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. This theory has been limited, however, by an inability to identify and isolate individual senescent cells within an intact organism. T...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Liu, Jie-Yu, Souroullas, George P., Diekman, Brian O., Krishnamurthy, Janakiraman, Hall, Brandon M., Sorrentino, Jessica A., Parker, Joel S., Sessions, Garrett A., Gudkov, Andrei V., Sharpless, Norman E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377452/
https://ncbi.nlm.nih.gov/pubmed/30683717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818313116
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