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Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. This theory has been limited, however, by an inability to identify and isolate individual senescent cells within an intact organism. T...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377452/ https://ncbi.nlm.nih.gov/pubmed/30683717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818313116 |
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