Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

BACKGROUND: Senescent cells, which express p16 (INK4a), accumulate with aging and contribute to age-related pathology. To understand whether cytotoxic agents promote molecular aging, we measured expression of p16 (INK4a) and other senescence markers in breast cancer patients treated with adjuvant ch...

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Main Authors: Sanoff, Hanna K., Deal, Allison M., Krishnamurthy, Janakiraman, Torrice, Chad, Dillon, Patrick, Sorrentino, Jessica, Ibrahim, Joseph G., Jolly, Trevor A., Williams, Grant, Carey, Lisa A., Drobish, Amy, Gordon, Brittaney-Belle, Alston, Shani, Hurria, Arti, Kleinhans, Karin, Rudolph, K. Lenhard, Sharpless, Norman E., Muss, Hyman B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982894/
https://ncbi.nlm.nih.gov/pubmed/24681605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju057
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