Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization

Por Verma, Rakesh, Kovari, Iulia, Soofi, Abdul, Nihalani, Deepak, Patrie, Kevin, Holzman, Lawrence B.
Publicado em 2006

P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs again...

Por Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.
Publicado no J Mol Graph Model (2013)

The Higher Barrier of Darunavir and Tipranavir Resistance for HIV-1 Protease

Por Wang, Yong, Liu, Zhigang, Brunzelle, Joseph S., Kovari, Iulia A., Dewdney, Tamaria G., Reiter, Samuel J., Kovari, Ladislau C.
Publicado em 2011

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

Por Wang, Yong, Dewdney, Tamaria G., Liu, Zhigang, Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publicado em 2012

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF

Por Yedidi, Ravikiran S., Proteasa, Gheorghe, Martin, Philip D., Liu, Zhigang, Vickrey, John F., Kovari, Iulia A., Kovari, Ladislau C.
Publicado no J Mol Graph Model (2014)

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Por Yedidi, Ravikiran S., Liu, Zhigang, Wang, Yong, Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C., Gupta, Deepak
Publicado em 2012

Conserved Hydrogen Bonds and Water Molecules in MDR HIV-1 Protease Substrate Complexes

Por Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publicado no Biochem Biophys Res Commun (2012)

Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance

Por Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publicado no Biochem Biophys Res Commun (2013)

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

Por Yedidi, Ravikiran S., Proteasa, Georghe, Martinez, Jorge L., Vickrey, John F., Martin, Philip D., Wawrzak, Zdzislaw, Liu, Zhigang, Kovari, Iulia A., Kovari, Ladislau C.
Publicado em 2011

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HI...

Por Yedidi, Ravikiran S., Muhuhi, Joseck M., Liu, Zhigang, Bencze, Krisztina Z., Koupparis, Kyriacos M., O'Connor, Carrie E., Kovari, Iulia A., Spaller, Mark R., Kovari, Ladislau C.
Publicado no Biochem Biophys Res Commun (2013)

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Por Kuiper, Benjamin D., Keusch, Bradley J., Dewdney, Tamaria G., Chordia, Poorvi, Ross, Kyla, Brunzelle, Joseph S., Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
Publicado no Biochem Biophys Rep (2015)