OXPHOS mutations and neurodegeneration

Por Koopman, Werner J H, Distelmaier, Felix, Smeitink, Jan AM, Willems, Peter HGM
Publicado em 2013

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

Por Liemburg-Apers, Dania C., Willems, Peter H. G. M., Koopman, Werner J. H., Grefte, Sander
Publicado no Arch Toxicol (2015)

Photo-Induction and Automated Quantification of Reversible Mitochondrial Permeability Transition Pore Opening in Primary Mouse Myotubes

Por Blanchet, Lionel, Grefte, Sander, Smeitink, Jan A. M., Willems, Peter H. G. M., Koopman, Werner J. H.
Publicado no PLoS One (2014)

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Por Forkink, Marleen, Basit, Farhan, Teixeira, José, Swarts, Herman G., Koopman, Werner J.H., Willems, Peter H.G.M.
Publicado no Redox Biol (2015)

The antioxidant Trolox restores mitochondrial membrane potential and Ca(2+)-stimulated ATP production in human complex I deficiency

Por Distelmaier, Felix, Visch, Henk-Jan, Smeitink, Jan A. M., Mayatepek, Ertan, Koopman, Werner J. H., Willems, Peter H. G. M.
Publicado em 2009

Modeling mitochondrial dysfunctions in the brain: from mice to men

Por Breuer, Megan E., Willems, Peter H. G. M., Russel, Frans G. M., Koopman, Werner J. H., Smeitink, Jan A. M.
Publicado em 2011

C. elegans ATAD-3 Is Essential for Mitochondrial Activity and Development

Por Hoffmann, Michael, Bellance, Nadège, Rossignol, Rodrigue, Koopman, Werner J. H., Willems, Peter H. G. M., Mayatepek, Ertan, Bossinger, Olaf, Distelmaier, Felix
Publicado em 2009

Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux

Por Liemburg-Apers, Dania C., Schirris, Tom J.J., Russel, Frans G.M., Willems, Peter H.G.M., Koopman, Werner J.H.
Publicado no Biophys J (2015)

Function and Regulation of the Na(+)-Ca(2+) Exchanger NCX3 Splice Variants in Brain and Skeletal Muscle

Por Michel, Lauriane Y. M., Verkaart, Sjoerd, Koopman, Werner J. H., Willems, Peter H. G. M., Hoenderop, Joost G. J., Bindels, René J. M.
Publicado em 2014

Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties

Por Nikolaisen, Julie, Nilsson, Linn I. H., Pettersen, Ina K. N., Willems, Peter H. G. M., Lorens, James B., Koopman, Werner J. H., Tronstad, Karl J.
Publicado em 2014

Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia

Por Manjeri, Ganesh R., Rodenburg, Richard J., Blanchet, Lionel, Roelofs, Suzanne, Nijtmans, Leo G., Smeitink, Jan A., Driessen, Jacques J., Koopman, Werner J. H., Willems, Peter H.
Publicado no J Inherit Metab Dis (2015)

Solute diffusion is hindered in the mitochondrial matrix

Por Dieteren, Cindy E. J., Gielen, Stan C. A. M., Nijtmans, Leo G. J., Smeitink, Jan A. M., Swarts, Herman G., Brock, Roland, Willems, Peter H. G. M., Koopman, Werner J. H.
Publicado em 2011

Mitochondrial function and morphology are impaired in parkin mutant fibroblasts

Por Mortiboys, Heather, Thomas, Kelly Jean, Koopman, Werner J.H., Klaffke, Stefanie, Abou-Sleiman, Patrick, Olpin, Simon, Wood, Nicholas W, Willems, Peter H.G.M., Smeitink, Jan A.M., Cookson, Mark R, Bandmann, Oliver
Publicado em 2008

Subunits of Mitochondrial Complex I Exist as Part of Matrix- and Membrane-associated Subcomplexes in Living Cells

Por Dieteren, Cindy E. J., Willems, Peter H. G. M., Vogel, Rutger O., Swarts, Herman G., Fransen, Jack, Roepman, Ronald, Crienen, Gijs, Smeitink, Jan A. M., Nijtmans, Leo G. J., Koopman, Werner J. H.
Publicado em 2008

Trolox-Sensitive Reactive Oxygen Species Regulate Mitochondrial Morphology, Oxidative Phosphorylation and Cytosolic Calcium Handling in Healthy Cells

Por Distelmaier, Felix, Valsecchi, Federica, Forkink, Marleen, van Emst-de Vries, Sjenet, Swarts, Herman G., Rodenburg, Richard J.T., Verwiel, Eugène T.P., Smeitink, Jan A.M., Willems, Peter H.G.M., Koopman, Werner J.H.
Publicado em 2012

Subunit-specific Incorporation Efficiency and Kinetics in Mitochondrial Complex I Homeostasis

Por Dieteren, Cindy E. J., Koopman, Werner J. H., Swarts, Herman G., Peters, Janny G. P., Maczuga, Piotr, van Gemst, Jasper J., Masereeuw, Rosalinde, Smeitink, Jan A. M., Nijtmans, Leo G. J., Willems, Peter H. G. M.
Publicado em 2012

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

Por Blanchet, Lionel, Smeitink, Jan A. M., van Emst - de Vries, Sjenet E., Vogels, Caroline, Pellegrini, Mina, Jonckheere, An I., Rodenburg, Richard J. T., Buydens, Lutgarde M. C., Beyrath, Julien, Willems, Peter H. G. M., Koopman, Werner J. H.
Publicado no Sci Rep (2015)

Insights into the Genome of Large Sulfur Bacteria Revealed by Analysis of Single Filaments

Por Mußmann, Marc, Hu, Fen Z, Richter, Michael, de Beer, Dirk, Preisler, André, Jørgensen, Bo B, Huntemann, Marcel, Glöckner, Frank Oliver, Amann, Rudolf, Koopman, Werner J. H, Lasken, Roger S, Janto, Benjamin, Hogg, Justin, Stoodley, Paul, Boissy, Robert, Ehrlich, Garth D
Publicado em 2007

Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly

Por Vogel, Rutger O., Janssen, Rolf J.R.J., van den Brand, Mariël A.M., Dieteren, Cindy E.J., Verkaart, Sjoerd, Koopman, Werner J.H., Willems, Peter H.G.M., Pluk, Wendy, van den Heuvel, Lambert P.W.J., Smeitink, Jan A.M., Nijtmans, Leo G.J.
Publicado em 2007