Subunits of Mitochondrial Complex I Exist as Part of Matrix- and Membrane-associated Subcomplexes in Living Cells

Mitochondrial complex I (CI) is a large assembly of 45 different subunits, and defects in its biogenesis are the most frequent cause of mitochondrial disorders. In vitro evidence suggests a stepwise assembly process involving pre-assembled modules. However, whether these modules also exist in vivo i...

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Detalhes bibliográficos
Main Authors: Dieteren, Cindy E. J., Willems, Peter H. G. M., Vogel, Rutger O., Swarts, Herman G., Fransen, Jack, Roepman, Ronald, Crienen, Gijs, Smeitink, Jan A. M., Nijtmans, Leo G. J., Koopman, Werner J. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259887/
https://ncbi.nlm.nih.gov/pubmed/18826940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807323200
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