Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia

We reported before that the minimal alveolar concentration (MAC) of isoflurane is decreased in complex I-deficient mice lacking the NDUFS4 subunit of the respiratory chain (RC) (1.55 and 0.81 % at postnatal (PN) 22–25 days and 1.68 and 0.65 % at PN 31–34 days for wildtype (WT) and CI-deficient KO, r...

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Bibliografiska uppgifter
I publikationen:J Inherit Metab Dis
Huvudupphovsmän: Manjeri, Ganesh R., Rodenburg, Richard J., Blanchet, Lionel, Roelofs, Suzanne, Nijtmans, Leo G., Smeitink, Jan A., Driessen, Jacques J., Koopman, Werner J. H., Willems, Peter H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Netherlands 2015
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710641/
https://ncbi.nlm.nih.gov/pubmed/26310962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-015-9885-x
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