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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberrations constitute linked therapeutic targets for small...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306129/ https://ncbi.nlm.nih.gov/pubmed/25620325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08035 |
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