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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberrations constitute linked therapeutic targets for small...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306129/ https://ncbi.nlm.nih.gov/pubmed/25620325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08035 |
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