Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberrations constitute linked therapeutic targets for small...

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Publicado en:Sci Rep
Autores principales: Blanchet, Lionel, Smeitink, Jan A. M., van Emst - de Vries, Sjenet E., Vogels, Caroline, Pellegrini, Mina, Jonckheere, An I., Rodenburg, Richard J. T., Buydens, Lutgarde M. C., Beyrath, Julien, Willems, Peter H. G. M., Koopman, Werner J. H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306129/
https://ncbi.nlm.nih.gov/pubmed/25620325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08035
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