Function and Regulation of the Na(+)-Ca(2+) Exchanger NCX3 Splice Variants in Brain and Skeletal Muscle

Isoform 3 of the Na(+)-Ca(2+) exchanger (NCX3) is crucial for maintaining intracellular calcium ([Ca(2+)](i)) homeostasis in excitable tissues. In this sense NCX3 plays a key role in neuronal excitotoxicity and Ca(2+) extrusion during skeletal muscle relaxation. Alternative splicing generates two va...

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Bibliographic Details
Main Authors: Michel, Lauriane Y. M., Verkaart, Sjoerd, Koopman, Werner J. H., Willems, Peter H. G. M., Hoenderop, Joost G. J., Bindels, René J. M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036267/
https://ncbi.nlm.nih.gov/pubmed/24616101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529388
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