Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Inhibitor studies with isolated mitochondria demonstrated that complex I (CI) and III (CIII) of the electron transport chain (ETC) can act as relevant sources of mitochondrial reactive oxygen species (ROS). Here we studied ROS generation and oxidative stress induction during chronic (24 h) inhibitio...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Forkink, Marleen, Basit, Farhan, Teixeira, José, Swarts, Herman G., Koopman, Werner J.H., Willems, Peter H.G.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635408/
https://ncbi.nlm.nih.gov/pubmed/26516986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.09.003
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