Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Inhibitor studies with isolated mitochondria demonstrated that complex I (CI) and III (CIII) of the electron transport chain (ETC) can act as relevant sources of mitochondrial reactive oxygen species (ROS). Here we studied ROS generation and oxidative stress induction during chronic (24 h) inhibitio...

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Publicat a:Redox Biol
Autors principals: Forkink, Marleen, Basit, Farhan, Teixeira, José, Swarts, Herman G., Koopman, Werner J.H., Willems, Peter H.G.M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635408/
https://ncbi.nlm.nih.gov/pubmed/26516986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.09.003
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