Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

The extracellular pH (pHe) is a key determinant of the cellular (micro)environment and needs to be maintained within strict boundaries to allow normal cell function. Here we used HEK293 cells to study the effects of pHe acidification (24 h), induced by mitochondrial inhibitors (rotenone, antimycin A...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Teixeira, José, Basit, Farhan, Swarts, Herman G., Forkink, Marleen, Oliveira, Paulo J., Willems, Peter H.G.M., Koopman, Werner J.H.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767902/
https://ncbi.nlm.nih.gov/pubmed/29331741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.12.018
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