Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 (‘BAY') triggers death of BRAF(V600E) melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death. BAY treatment depolarized the mitoc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Basit, Farhan, van Oppen, Lisanne MPE, Schöckel, Laura, Bossenbroek, Hasse M, van Emst-de Vries, Sjenet E, Hermeling, Johannes CW, Grefte, Sander, Kopitz, Charlotte, Heroult, Melanie, HGM Willems, Peter, Koopman, Werner JH
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386536/
https://ncbi.nlm.nih.gov/pubmed/28358377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.133
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