Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth

BACKGROUND: Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. In this study, we investigated the effects of BAY 87-2243, a small molecule tha...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Schöckel, Laura, Glasauer, Andrea, Basit, Farhan, Bitschar, Katharina, Truong, Hoa, Erdmann, Gerrit, Algire, Carolyn, Hägebarth, Andrea, Willems, Peter HGM, Kopitz, Charlotte, Koopman, Werner JH, Héroult, Mélanie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615872/
https://ncbi.nlm.nih.gov/pubmed/26500770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0138-0
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