(18)F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243

PURPOSE: We describe a non-invasive PET imaging method that monitors early therapeutic efficacy of BAY 87-2243, a novel small molecule inhibitor of mitochondrial complex I as a function of hypoxia-inducible factor-1α (HIF-1α) activity EXPERIMENTAL DESIGN: Four PET tracers ((18)F-FDG, (18)F-Fpp(RGD)(...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Chang, Edwin, Liu, Hongguang, Unterschemmann, Kerstin, Ellinghaus, Peter, Liu, Shuanglong, Gekeler, Volker, Cheng, Zhen, Berndorff, Dietmar, Gambhir, Sanjiv S
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297600/
https://ncbi.nlm.nih.gov/pubmed/25381339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0217
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