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(18)F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243
PURPOSE: We describe a non-invasive PET imaging method that monitors early therapeutic efficacy of BAY 87-2243, a novel small molecule inhibitor of mitochondrial complex I as a function of hypoxia-inducible factor-1α (HIF-1α) activity EXPERIMENTAL DESIGN: Four PET tracers ((18)F-FDG, (18)F-Fpp(RGD)(...
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| izdano v: | Clin Cancer Res |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297600/ https://ncbi.nlm.nih.gov/pubmed/25381339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0217 |
| Oznake: |
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