Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 (‘BAY') triggers death of BRAF(V600E) melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death. BAY treatment depolarized the mitoc...

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Опубликовано в: :Cell Death Dis
Главные авторы: Basit, Farhan, van Oppen, Lisanne MPE, Schöckel, Laura, Bossenbroek, Hasse M, van Emst-de Vries, Sjenet E, Hermeling, Johannes CW, Grefte, Sander, Kopitz, Charlotte, Heroult, Melanie, HGM Willems, Peter, Koopman, Werner JH
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386536/
https://ncbi.nlm.nih.gov/pubmed/28358377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.133
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