Cathepsin K-Cre Causes Unexpected Germline Deletion of Genes in Mice

Por Winkeler, Crystal L., Kladney, Raleigh D., Maggi, Leonard B., Weber, Jason D.
Publicado em 2012

HYPOXIA-INDUCIBLE FACTOR-1α SUPPRESSES SQUAMOUS CARCINOGENIC PROGRESSION AND EPITHELIAL MESENCHYMAL TRANSITION

Por Scortegagna, Marzia, Martin, Rebecca J., Kladney, Raleigh D., Neumann, Robert G., Arbeit, Jeffrey M.
Publicado em 2009

Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice

Por Kladney, Raleigh D., Cardiff, Robert D., Kwiatkowski, David J., Chiang, Gary G., Weber, Jason D., Arbeit, Jeffrey M., Lu, Zhi Hong
Publicado em 2010

RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis

Por Saporita, Anthony J., Chang, Hsiang-Chun, Winkeler, Crystal L., Apicelli, Anthony J., Kladney, Raleigh D., Wang, Jianbo, Townsend, R. Reid, Michel, Loren S., Weber, Jason D.
Publicado em 2011

Selective targeting of point-mutated KRAS through artificial microRNAs

Por Acunzo, Mario, Romano, Giulia, Nigita, Giovanni, Veneziano, Dario, Fattore, Luigi, Laganà, Alessandro, Zanesi, Nicola, Fadda, Paolo, Fassan, Matteo, Rizzotto, Lara, Kladney, Raleigh, Coppola, Vincenzo, Croce, Carlo M.
Publicado no Proc Natl Acad Sci U S A (2017)

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

Por Wang, Jianbo, Zhang, Kaihua, Grabowska, Dorota, Li, Aimin, Dong, Yiyu, Day, Ryan, Humphrey, Peter, Lewis, James, Kladney, Raleigh D., Arbeit, Jeffrey M., Weber, Jason D., Chung, Christine H., Michel, Loren S.
Publicado em 2011

mTOR Activator Rheb Is Frequently Overexpressed In Human Carcinomas And Is Critical And Sufficient For Skin Epithelial Carcinogenesis

Por Lu, Zhi Hong, Shvartsman, Mark B., Lee, Andrew Y., Shao, Jenny M., Murray, Mollianne M., Kladney, Raleigh D., Fan, Dong, Krajewski, Stan, Chiang, Gary G., Mills, Gordon B., Arbeit, Jeffrey M.
Publicado em 2010

Redeployment of Myc and E2f1-3 drives Rb deficient cell cycles

Por Liu, Huayang, Tang, Xing, Srivastava, Arunima, Pécot, Thierry, Daniel, Piotr, Hemmelgarn, Benjamin, Reyes, Stephan, Fackler, Nicholas, Bajwa, Amneet, Kladney, Raleigh, Koivisto, Christopher, Chen, Zhong, Wang, Qianben, Huang, Kun, Machiraju, Raghu, Sáenz-Robles, Maria Teresa, Cantalupo, Paul, Pipas, James M., Leone, Gustavo
Publicado no Nat Cell Biol (2015)

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

Por Ratnam, Nivedita M., Peterson, Jennifer M., Talbert, Erin E., Ladner, Katherine J., Rajasekera, Priyani V., Schmidt, Carl R., Dillhoff, Mary E., Swanson, Benjamin J., Haverick, Ericka, Kladney, Raleigh D., Williams, Terence M., Leone, Gustavo W., Wang, David J., Guttridge, Denis C.
Publicado no J Clin Invest (2017)

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

Por Hammer, Anisha M., Sizemore, Gina M., Shukla, Vasudha C., Avendano, Alex, Sizemore, Steven T., Chang, Jonathan J., Kladney, Raleigh D., Cuitiño, Maria C., Thies, Katie A., Verfurth, Quinn, Chakravarti, Arnab, Yee, Lisa D., Leone, Gustavo, Song, Jonathan W., Ghadiali, Samir N., Ostrowski, Michael C.
Publicado no Neoplasia (2017)

Golgi Protein GOLM1 Is a Tissue and Urine Biomarker of Prostate Cancer

Por Varambally, Sooryanarayana, Laxman, Bharathi, Mehra, Rohit, Cao, Qi, Dhanasekaran, Saravana M, Tomlins, Scott A, Granger, Jill, Vellaichamy, Adaikkalam, Sreekumar, Arun, Yu, Jianjun, Gu, Wenjuan, Shen, Ronglai, Ghosh, Debashis, Wright, Lorinda M, Kladney, Raleigh D, Kuefer, Rainer, Rubin, Mark A, Fimmel, Claus J, Chinnaiyan, Arul M
Publicado em 2008

Ets2 in Tumor Fibroblasts Promotes Angiogenesis in Breast Cancer

Por Wallace, Julie A., Li, Fu, Balakrishnan, Subhasree, Cantemir-Stone, Carmen Z., Pecot, Thierry, Martin, Chelsea, Kladney, Raleigh D., Sharma, Sudarshana M., Trimboli, Anthony J., Fernandez, Soledad A., Yu, Lianbo, Rosol, Thomas J., Stromberg, Paul C., Lesurf, Robert, Hallett, Michael, Park, Morag, Leone, Gustavo, Ostrowski, Michael C.
Publicado em 2013

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

Por Kent, Lindsey N., Bae, Sooin, Tsai, Shih-Yin, Tang, Xing, Srivastava, Arunima, Koivisto, Christopher, Martin, Chelsea K., Ridolfi, Elisa, Miller, Grace C., Zorko, Sarah M., Plevris, Emilia, Hadjiyannis, Yannis, Perez, Miguel, Nolan, Eric, Kladney, Raleigh, Westendorp, Bart, de Bruin, Alain, Fernandez, Soledad, Rosol, Thomas J., Pohar, Kamal S., Pipas, James M., Leone, Gustavo
Publicado no J Clin Invest (2017)

Interleukin-18 drives ILC3 proliferation and promotes interleukin-22 production via NF-κB()

Por Victor, Aaron R., Nalin, Ansel P., Dong, Wenjuan, McClory, Susan, Wei, Min, Mao, Charlene, Kladney, Raleigh D., Youssef, Youssef, Chan, Wing Keung, Briercheck, Edward L., Hughes, Tiffany, Scoville, Steven D., Pitarresi, Jason R., Chen, Charlie, Manz, Sarah, Wu, Lai-Chu, Zhang, Jianying, Ostrowski, Michael C., Freud, Aharon G., Leone, Gustavo W., Caligiuri, Michael A., Yu, Jianhua
Publicado no J Immunol (2017)

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia()

Por Pitarresi, Jason R., Liu, Xin, Sharma, Sudarshana M., Cuitiño, Maria C., Kladney, Raleigh D., Mace, Thomas A., Donohue, Sydney, Nayak, Sunayana G., Qu, Chunjing, Lee, James, Woelke, Sarah A., Trela, Stefan, LaPak, Kyle, Yu, Lianbo, McElroy, Joseph, Rosol, Thomas J., Shakya, Reena, Ludwig, Thomas, Lesinski, Gregory B., Fernandez, Soledad A., Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Publicado no Neoplasia (2016)

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

Por Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Publicado no Genes Dev (2016)

E2f8 mediates tumor suppression in postnatal liver development

Por Kent, Lindsey N., Rakijas, Jessica B., Pandit, Shusil K., Westendorp, Bart, Chen, Hui-Zi, Huntington, Justin T., Tang, Xing, Bae, Sooin, Srivastava, Arunima, Senapati, Shantibhusan, Koivisto, Christopher, Martin, Chelsea K., Cuitino, Maria C., Perez, Miguel, Clouse, Julian M., Chokshi, Veda, Shinde, Neelam, Kladney, Raleigh, Sun, Daokun, Perez-Castro, Antonio, Matondo, Ramadhan B., Nantasanti, Sathidpak, Mokry, Michal, Huang, Kun, Machiraju, Raghu, Fernandez, Soledad, Rosol, Thomas J., Coppola, Vincenzo, Pohar, Kamal S., Pipas, James M., Schmidt, Carl R., de Bruin, Alain, Leone, Gustavo
Publicado no J Clin Invest (2016)

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Por Caserta, Enrico, Egriboz, Onur, Wang, Hui, Martin, Chelsea, Koivisto, Christopher, Pecót, Thierry, Kladney, Raleigh D., Shen, Changxian, Shim, Kang-Sup, Pham, Thac, Karikomi, Matthew K., Mauntel, Melissa J., Majumder, Sarmila, Cuitino, Maria C., Tang, Xing, Srivastava, Arunima, Yu, Lianbo, Wallace, Julie, Mo, Xiaokui, Park, Morag, Fernandez, Soledad A., Pilarski, Robert, La Perle, Krista M.D., Rosol, Thomas J., Coppola, Vincenzo, Castrillon, Diego H., Timmers, Cynthia, Cohn, David E., O'Malley, David M., Backes, Floor, Suarez, Adrian A., Goodfellow, Paul, Chamberlin, Helen M., Macrae, Erin R., Shapiro, Charles L., Ostrowski, Michael C., Leone, Gustavo
Publicado no Genes Dev (2015)

Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Por Liu, Huayang, Dowdle, James A., Khurshid, Safiya, Sullivan, Nicholas J., Bertos, Nicholas, Rambani, Komal, Mair, Markus, Daniel, Piotr, Wheeler, Esther, Tang, Xing, Toth, Kyle, Lause, Michael, Harrigan, Markus E., Eiring, Karl, Sullivan, Connor, Sullivan, Matthew J., Chang, Serena W., Srivastava, Siddhant, Conway, Joseph S., Kladney, Raleigh, McElroy, Joseph, Bae, Sooin, Lu, Yuanzhi, Tofigh, Ali, Saleh, Sadiq M. I., Fernandez, Soledad A., Parvin, Jeffrey D., Coppola, Vincenzo, Macrae, Erin R., Majumder, Sarmila, Shapiro, Charles L., Yee, Lisa D., Ramaswamy, Bhuvaneswari, Hallett, Michael, Ostrowski, Michael C., Park, Morag, Chamberlin, Helen M., Leone, Gustavo
Publicado no Dev Cell (2017)