Selective targeting of point-mutated KRAS through artificial microRNAs

Mutated protein-coding genes drive the molecular pathogenesis of many diseases, including cancer. Specifically, mutated KRAS is a documented driver for malignant transformation, occurring early during the pathogenesis of cancers such as lung and pancreatic adenocarcinomas. Therapeutically, the indis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Acunzo, Mario, Romano, Giulia, Nigita, Giovanni, Veneziano, Dario, Fattore, Luigi, Laganà, Alessandro, Zanesi, Nicola, Fadda, Paolo, Fassan, Matteo, Rizzotto, Lara, Kladney, Raleigh, Coppola, Vincenzo, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448175/
https://ncbi.nlm.nih.gov/pubmed/28484014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620562114
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