miR-579-3p controls melanoma progression and resistance to target therapy

Therapy of melanoma patients harboring activating mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) oncogene with a combination of BRAF and MEK inhibitors is plagued by the development of drug resistance. Mutational events, as well as adaptive mechanisms, contribute to the devel...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fattore, Luigi, Mancini, Rita, Acunzo, Mario, Romano, Giulia, Laganà, Alessandro, Pisanu, Maria Elena, Malpicci, Debora, Madonna, Gabriele, Mallardo, Domenico, Capone, Marilena, Fulciniti, Franco, Mazzucchelli, Luca, Botti, Gerardo, Croce, Carlo M., Ascierto, Paolo Antonio, Ciliberto, Gennaro
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003278/
https://ncbi.nlm.nih.gov/pubmed/27503895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607753113
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