ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

In recent years the introduction of target therapies with BRAF and MEK inhibitors (MAPKi) and of immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies have dramatically improved survival of metastatic melanoma patients. Despite these changes drug resistance remains a major hurdle. Sever...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Ruggiero, Ciro Francesco, Malpicci, Debora, Fattore, Luigi, Madonna, Gabriele, Vanella, Vito, Mallardo, Domenico, Liguoro, Domenico, Salvati, Valentina, Capone, Mariaelena, Bedogni, Barbara, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826737/
https://ncbi.nlm.nih.gov/pubmed/31557826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101425
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