ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

In recent years the introduction of target therapies with BRAF and MEK inhibitors (MAPKi) and of immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies have dramatically improved survival of metastatic melanoma patients. Despite these changes drug resistance remains a major hurdle. Sever...

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Publicado en:Cancers (Basel)
Main Authors: Ruggiero, Ciro Francesco, Malpicci, Debora, Fattore, Luigi, Madonna, Gabriele, Vanella, Vito, Mallardo, Domenico, Liguoro, Domenico, Salvati, Valentina, Capone, Mariaelena, Bedogni, Barbara, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826737/
https://ncbi.nlm.nih.gov/pubmed/31557826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101425
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