Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma

by Fattore, Luigi, Mancini, Rita, Ciliberto, Gennaro
Published in Cancers (Basel) (2020)

Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma

by Fattore, Luigi, Ruggiero, Ciro Francesco, Liguoro, Domenico, Mancini, Rita, Ciliberto, Gennaro
Published in Cell Death Dis (2019)

The Promise of Liquid Biopsy to Predict Response to Immunotherapy in Metastatic Melanoma

by Fattore, Luigi, Ruggiero, Ciro Francesco, Liguoro, Domenico, Castaldo, Vittorio, Catizone, Angiolina, Ciliberto, Gennaro, Mancini, Rita
Published in Front Oncol (2021)

MicroRNAs in melanoma development and resistance to target therapy

by Fattore, Luigi, Costantini, Susan, Malpicci, Debora, Ruggiero, Ciro Francesco, Ascierto, Paolo Antonio, Croce, Carlo M., Mancini, Rita, Ciliberto, Gennaro
Published in Oncotarget (2017)

Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane...

by Fattore, Luigi, Malpicci, Debora, Milite, Ciro, Castellano, Sabrina, Sbardella, Gianluca, Botti, Gerardo, Ascierto, Paolo A., Mancini, Rita, Ciliberto, Gennaro
Published in Cell Commun Signal (2020)

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells

by Leonetti, Erica, Gesualdi, Luisa, Corano Scheri, Katia, Dinicola, Simona, Fattore, Luigi, Masiello, Maria Grazia, Cucina, Alessandra, Mancini, Rita, Bizzarri, Mariano, Ricci, Giulia, Catizone, Angela
Published in Int J Mol Sci (2019)

In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metasta...

by Fattore, Luigi, Campani, Virginia, Ruggiero, Ciro Francesco, Salvati, Valentina, Liguoro, Domenico, Scotti, Lorena, Botti, Gerardo, Ascierto, Paolo Antonio, Mancini, Rita, De Rosa, Giuseppe, Ciliberto, Gennaro
Published in Int J Mol Sci (2020)

Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies

by Fattore, Luigi, Marra, Emanuele, Pisanu, Maria Elena, Noto, Alessia, de Vitis, Claudia, Belleudi, Francesca, Aurisicchio, Luigi, Mancini, Rita, Torrisi, Maria Rosaria, Ascierto, Paolo Antonio, Ciliberto, Gennaro
Published 2013

Activation of the ErbB3-AKT axis promotes melanoma cell survival and proliferation in response to RAF/MEK inhibition

by Fattore, Luigi, Marra, Emanuele, Pisanu, Maria Elena, Noto, Alessia, De Vitis, Claudia, Belleudi, Francesca, Aurisicchio, Luigi, Mancini, Rita, Torrisi, Maria Rosaria, Ascierto, Paolo Antonio, Ciliberto, Gennaro
Published 2014

ErbB3 plays a key role in the early phase of establishment of resistance to BRAF and/or MEK inhibitors

by Fattore, Luigi, Malpicci, Debora, Marra, Emanuele, Camerlingo, Rosalba, Roscilli, Giuseppe, Belleudi, Francesca, Ribas, Antoni, Mancini, Rita, Torrisi, Maria Rosaria, Aurisicchio, Luigi, Ascierto, Paolo Antonio, Ciliberto, Gennaro
Published in J Transl Med (2015)

Selective targeting of point-mutated KRAS through artificial microRNAs

by Acunzo, Mario, Romano, Giulia, Nigita, Giovanni, Veneziano, Dario, Fattore, Luigi, Laganà, Alessandro, Zanesi, Nicola, Fadda, Paolo, Fassan, Matteo, Rizzotto, Lara, Kladney, Raleigh, Coppola, Vincenzo, Croce, Carlo M.
Published in Proc Natl Acad Sci U S A (2017)

ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Aut...

by Ruggiero, Ciro Francesco, Malpicci, Debora, Fattore, Luigi, Madonna, Gabriele, Vanella, Vito, Mallardo, Domenico, Liguoro, Domenico, Salvati, Valentina, Capone, Mariaelena, Bedogni, Barbara, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Published in Cancers (Basel) (2019)

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer

by Noto, Alessia, De Vitis, Claudia, Roscilli, Giuseppe, Fattore, Luigi, Malpicci, Debora, Marra, Emanuele, Luberto, Laura, D'Andrilli, Antonio, Coluccia, Pierpaolo, Giovagnoli, Maria Rosaria, Normanno, Nicola, Ruco, Luigi, Aurisicchio, Luigi, Mancini, Rita, Ciliberto, Gennaro
Published 2013

TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung

by Ricci, Alberto, De Vitis, Claudia, Noto, Alessia, Fattore, Luigi, Mariotta, Salvatore, Cherubini, Emanuela, Roscilli, Giuseppe, Liguori, Giuseppina, Scognamiglio, Giosuè, Rocco, Gaetano, Botti, Gerardo, Giarnieri, Enrico, Giovagnoli, Maria Rosaria, De Toma, Giorgio, Ciliberto, Gennaro, Mancini, Rita
Published 2013

miR-579-3p controls melanoma progression and resistance to target therapy

by Fattore, Luigi, Mancini, Rita, Acunzo, Mario, Romano, Giulia, Laganà, Alessandro, Pisanu, Maria Elena, Malpicci, Debora, Madonna, Gabriele, Mallardo, Domenico, Capone, Marilena, Fulciniti, Franco, Mazzucchelli, Luca, Botti, Gerardo, Croce, Carlo M., Ascierto, Paolo Antonio, Ciliberto, Gennaro
Published in Proc Natl Acad Sci U S A (2016)

microRNA-378a-5p iS a novel positive regulator of melanoma progression

by Tupone, Maria Grazia, D’Aguanno, Simona, Di Martile, Marta, Valentini, Elisabetta, Desideri, Marianna, Trisciuoglio, Daniela, Donzelli, Sara, Sacconi, Andrea, Buglioni, Simonetta, Ercolani, Cristiana, Biagioni, Alessio, Fibbi, Gabriella, Fattore, Luigi, Mancini, Rita, Ciliberto, Gennaro, Blandino, Giovanni, Del Bufalo, Donatella
Published in Oncogenesis (2020)

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma

by Fattore, Luigi, Malpicci, Debora, Marra, Emanuele, Belleudi, Francesca, Noto, Alessia, De Vitis, Claudia, Pisanu, Maria Elena, Coluccia, Pierpaolo, Camerlingo, Rosa, Roscilli, Giuseppe, Ribas, Antoni, Di Napoli, Arianna, Torrisi, Maria Rosaria, Aurisicchio, Luigi, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Published in Oncotarget (2015)

CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions

by Bruschini, Sara, di Martino, Simona, Pisanu, Maria Elena, Fattore, Luigi, De Vitis, Claudia, Laquintana, Valentina, Buglioni, Simonetta, Tabbì, Eugenio, Cerri, Andrea, Visca, Paolo, Alessandrini, Gabriele, Facciolo, Francesco, Napoli, Christian, Trombetta, Marcella, Santoro, Antonio, Crescenzi, Anna, Ciliberto, Gennaro, Mancini, Rita
Published in J Cell Physiol (2019)

Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

by Fattore, Luigi, Ruggiero, Ciro Francesco, Pisanu, Maria Elena, Liguoro, Domenico, Cerri, Andrea, Costantini, Susan, Capone, Francesca, Acunzo, Mario, Romano, Giulia, Nigita, Giovanni, Mallardo, Domenico, Ragone, Concetta, Carriero, Maria Vincenza, Budillon, Alfredo, Botti, Gerardo, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Published in Cell Death Differ (2018)

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

by Pisanu, Maria Elena, Maugeri-Saccà, Marcello, Fattore, Luigi, Bruschini, Sara, De Vitis, Claudia, Tabbì, Eugenio, Bellei, Barbara, Migliano, Emilia, Kovacs, Daniela, Camera, Emanuela, Picardo, Mauro, Jakopin, Ziga, Cippitelli, Claudia, Bartolazzi, Armando, Raffa, Salvatore, Torrisi, Maria Rosaria, Fulciniti, Franco, Ascierto, Paolo A., Ciliberto, Gennaro, Mancini, Rita
Published in J Exp Clin Cancer Res (2018)