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Cathepsin K-Cre Causes Unexpected Germline Deletion of Genes in Mice

Osteoclasts are terminally differentiated cells that attach to bone and secrete proteases to degrade the bone matrix. The primary protease responsible for the degradation of the organic component of the bone matrix is Cathepsin K, which was largely thought to be unique to osteoclasts. Given its appa...

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Detalhes bibliográficos
Main Authors: Winkeler, Crystal L., Kladney, Raleigh D., Maggi, Leonard B., Weber, Jason D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409209/
https://ncbi.nlm.nih.gov/pubmed/22860046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042005
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