Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the st...

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Bibliografski detalji
Izdano u:Neoplasia
Glavni autori: Hammer, Anisha M., Sizemore, Gina M., Shukla, Vasudha C., Avendano, Alex, Sizemore, Steven T., Chang, Jonathan J., Kladney, Raleigh D., Cuitiño, Maria C., Thies, Katie A., Verfurth, Quinn, Chakravarti, Arnab, Yee, Lisa D., Leone, Gustavo, Song, Jonathan W., Ghadiali, Samir N., Ostrowski, Michael C.
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press 2017
Teme:
Original article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440288/
https://ncbi.nlm.nih.gov/pubmed/28501760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.04.004
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