Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the st...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Hammer, Anisha M., Sizemore, Gina M., Shukla, Vasudha C., Avendano, Alex, Sizemore, Steven T., Chang, Jonathan J., Kladney, Raleigh D., Cuitiño, Maria C., Thies, Katie A., Verfurth, Quinn, Chakravarti, Arnab, Yee, Lisa D., Leone, Gustavo, Song, Jonathan W., Ghadiali, Samir N., Ostrowski, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2017
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440288/
https://ncbi.nlm.nih.gov/pubmed/28501760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.04.004
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