Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in...

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Pubblicato in:Genes Dev
Autori principali: Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066238/
https://ncbi.nlm.nih.gov/pubmed/27633013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283499.116
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