Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1

Fibroblasts within the mammary tumor microenvironment are active participants in carcinogenesis mediating both tumor initiation and progression. Our group has previously demonstrated that genetic loss of PTEN in mammary fibroblasts induces an oncogenic secretome that remodels the extracellular milie...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Sizemore, GM, Balakrishnan, S, Hammer, AM, Thies, KA, Trimboli, AJ, Wallace, JA, Sizemore, ST, Kladney, RD, Woelke, SA, Yu, L, Fernandez, SA, Chakravarti, A, Leone, G, Ostrowski, MC
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398932/
https://ncbi.nlm.nih.gov/pubmed/27797378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.383
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