Pten in Stromal Fibroblasts Suppresses Mammary Epithelial Tumors

The tumor stroma is believed to contribute to some of the most malignant characteristics of epithelial tumors. However, signaling between stromal and tumor cells is complex and remains poorly understood. Here we show that the genetic inactivation of Pten in stromal fibroblasts of mouse mammary gland...

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Auteurs principaux: Trimboli, Anthony J., Cantemir-Stone, Carmen Z., Li, Fu, Wallace, Julie A., Merchant, Anand, Creasap, Nicholas, Thompson, John C., Caserta, Enrico, Wang, Hui, Chong, Jean-Leon, Naidu, Shan, Wei, Guo, Sharma, Sudarshana M., Stephens, Julie A., Fernandez, Soledad A., Gurcan, Metin N., Weinstein, Michael B., Barsky, Sanford H., Yee, Lisa, Rosol, Thomas J., Stromberg, Paul C., Robinson, Michael L., Pepin, Francois, Hallett, Michael, Park, Morag, Ostrowski, Michael C., Leone, Gustavo
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767301/
https://ncbi.nlm.nih.gov/pubmed/19847259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08486
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