Allele-specific tumor spectrum in Pten knockin mice

Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden and Bannayan–Riley–Ruvalcaba (BRR) syndromes, two dominantly inherited disorders characterized by mental retardation, multiple hamartomas, and variable cancer risk. Here, we m...

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Detalhes bibliográficos
Main Authors: Wang, Hui, Karikomi, Matt, Naidu, Shan, Rajmohan, Ravi, Caserta, Enrico, Chen, Hui-Zi, Rawahneh, Maysoon, Moffitt, Julie, Stephens, Julie A., Fernandez, Soledad A., Weinstein, Michael, Wang, Danxin, Sadee, Wolfgang, La Perle, Krista, Stromberg, Paul, Rosol, Thomas J., Eng, Charis, Ostrowski, Michael C., Leone, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841921/
https://ncbi.nlm.nih.gov/pubmed/20194734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912524107
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