Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K–AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 (Pten(FV)), fo...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Caserta, Enrico, Egriboz, Onur, Wang, Hui, Martin, Chelsea, Koivisto, Christopher, Pecót, Thierry, Kladney, Raleigh D., Shen, Changxian, Shim, Kang-Sup, Pham, Thac, Karikomi, Matthew K., Mauntel, Melissa J., Majumder, Sarmila, Cuitino, Maria C., Tang, Xing, Srivastava, Arunima, Yu, Lianbo, Wallace, Julie, Mo, Xiaokui, Park, Morag, Fernandez, Soledad A., Pilarski, Robert, La Perle, Krista M.D., Rosol, Thomas J., Coppola, Vincenzo, Castrillon, Diego H., Timmers, Cynthia, Cohn, David E., O'Malley, David M., Backes, Floor, Suarez, Adrian A., Goodfellow, Paul, Chamberlin, Helen M., Macrae, Erin R., Shapiro, Charles L., Ostrowski, Michael C., Leone, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561480/
https://ncbi.nlm.nih.gov/pubmed/26302789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262568.115
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